PCSK9: BIOLOGICAL ACTIVITY REGULATION AND CONNECTION WITH LIPID AND CARBOHYDRATE METABOLISM
نویسندگان
چکیده
منابع مشابه
PCSK9 and carbohydrate metabolism: A double-edged sword
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic d...
متن کاملThe Effect of Amino Acid, Carbohydrate, and Lipid Metabolism Disorders on Eyes
Inherited metabolic disorders (IMDs) are a class of genetic disorders. Each metabolic disorder may have different forms with different age of onset, clinical manifestations, severity, and even type of inheritance. Ideally, a group of different specialists, including ophthalmologists, pediatricians, biochemists, and medical geneticists are needed for the final diagnosis and management of IMDs. B...
متن کاملPCSK9 targets important for lipid metabolism
Ischemic heart disease is the main cause of death worldwide and it is accelerated by increased low-density lipoprotein (LDL) cholesterol (LDL-C) and/or lipoprotein (a) (Lp(a)) concentrations. Proprotein convertase subtilisin/kexin type 9 (PCSK9) alters both LDL-C and in part Lp(a) concentrations through its ability to induce degradation of the LDL receptor (LDLR). PCSK9, however, has additional...
متن کاملMalnutrition and Carbohydrate and Lipid Metabolism
This subject was last reviewed at the Chiang Mai Symposium on Protein-Calorie Malnutrition (PCM), which was held in January 1973 and published in 1975 (1). At that time, there had been nearly 20 years of exciting research since Trowell et al. (2) wrote the first comprehensive monograph on kwashiorkor in 1954. This chapter recapitulates what was known about the subject in 1973, brings it up to d...
متن کاملEffects of physical activity on carbohydrate and lipid metabolism in women with abdominal obesity
Introduction. The incidence of metabolic disorders in obese people is not only determined by the amount of adipose tissue but mainly by its distribution. Metabolic disorders may lead to the development of occupational metabolic diseases. Aim of Study. The aim of the study was to estimate the effects of increased physical activity in women with abdominal obesity on carbohydrate and lipid metabol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Practice
سال: 2017
ISSN: 2618-8627,2220-3095
DOI: 10.17816/clinpract8370-75